2020•New Journal of ChemistryRequires access

Encapsulation of oxime acetylcholinesterase reactivators: influence of physiological conditions on the stability of oxime-cucurbit[7]uril complexes

Rudolf Andrýs, Aneta Klusoňová, Miroslav Lísa, Jana Žďárová Karasová

Abstract

The influence of physiological conditions on the host–guest chemistry of oxime acetylcholinesterase reactivators with cucurbit[7]urile was investigated to increase their effectiveness for the treatment of organophosphate intoxication.

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Key concepts: Chemistry, Oxime, Acetylcholinesterase, Organophosphate, Medicinal chemistry, Stereochemistry, Organic chemistry, Enzyme