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2020•Infection and ImmunityOpen access

Microscopic and Submicroscopic Asymptomatic Plasmodium falciparum Infections in Ghanaian Children and Protection against Febrile Malaria

Bright Adu, Quratul-ain Issahaque, Tracy Sarkodie-Addo, Selassie Kumordjie, Eric Kyei‐Baafour, Caleb Kwame Sinclear, Sophia Eyia-Ampah, Eunice Owusu-Yeboa, Michael Theisen, Daniel Dodoo

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Abstract

Naturally acquired immunity to Plasmodium falciparum malaria is thought to be nonsterile and sustained by persistence of low-level parasitemia. This study assessed the association between baseline microscopic and submicroscopic asymptomatic P. falciparum infections and antimalarial antibody levels and whether these parasitemia modify protective associations between antibody levels and malaria in Ghanaian children. Healthy children ( N = 973, aged 0.

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What this paper is about

Naturally acquired immunity to Plasmodium falciparum malaria is thought to be nonsterile and sustained by persistence of low-level parasitemia. This study assessed the association between baseline microscopic and submicroscopic asymptomatic P. falciparum infections and antimalarial antibody levels and whether these parasitemia modify protective associations between antibody levels and malaria in Ghanaian children. Healthy children ( N = 973, aged 0.

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Available abstract

Naturally acquired immunity to Plasmodium falciparum malaria is thought to be nonsterile and sustained by persistence of low-level parasitemia. This study assessed the association between baseline microscopic and submicroscopic asymptomatic P. falciparum infections and antimalarial antibody levels and whether these parasitemia modify protective associations between antibody levels and malaria in Ghanaian children. Healthy children ( N = 973, aged 0.

Key concepts: Parasitemia, Asymptomatic, Malaria, Plasmodium falciparum, Hazard ratio, Immunology, Biology, Interquartile range

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