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2020•Journal of Clinical Pharmacy and TherapeuticsOpen access

Successful challenge of voriconazole in a patient with posaconazole‐associated minor drug eruption: A case report

Benjabhorn Weeraphon, Jakapat Vanichanan, Sang Usayaporn

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Abstract

WHAT IS KNOWN AND OBJECTIVE: Triazole antifungal-associated skin rash is rare. Data on cross-reaction triazole antifungals remain inconclusive and poorly defined. We report successful voriconazole challenge in a patient allergic to posaconazole. CASE SUMMARY: A 38-year-old female diagnosed with acute myeloid leukaemia and receiving chemotherapy treatment in our institution developed a maculopapular rash after receiving oral posaconazole for invasive fungal infection prophylaxis. Other potential causes that may have attributed to this response, such as other drugs that the patient was taking and infections, were excluded. Voriconazole, another triazole antifungal, was successfully substituted for posaconazole. WHAT IS NEW AND CONCLUSION: This is the first case report of a patient, with a history of posaconazole allergy, successfully challenged with voriconazole.

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WHAT IS KNOWN AND OBJECTIVE: Triazole antifungal-associated skin rash is rare. Data on cross-reaction triazole antifungals remain inconclusive and poorly defined. We report successful voriconazole challenge in a patient allergic to posaconazole. CASE SUMMARY: A 38-year-old female diagnosed with acute myeloid leukaemia and receiving chemotherapy treatment in our institution developed a maculopapular rash after receiving oral posaconazole for invasive fungal infection prophylaxis. Other potential causes that may have attributed to this response, such as other drugs that the patient was taking and infections, were excluded. Voriconazole, another triazole antifungal, was successfully substituted for posaconazole. WHAT IS NEW AND CONCLUSION: This is the first case report of a patient, with a history of posaconazole allergy, successfully challenged with voriconazole.

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Available abstract

WHAT IS KNOWN AND OBJECTIVE: Triazole antifungal-associated skin rash is rare. Data on cross-reaction triazole antifungals remain inconclusive and poorly defined. We report successful voriconazole challenge in a patient allergic to posaconazole. CASE SUMMARY: A 38-year-old female diagnosed with acute myeloid leukaemia and receiving chemotherapy treatment in our institution developed a maculopapular rash after receiving oral posaconazole for invasive fungal infection prophylaxis. Other potential causes that may have attributed to this response, such as other drugs that the patient was taking and infections, were excluded. Voriconazole, another triazole antifungal, was successfully substituted for posaconazole. WHAT IS NEW AND CONCLUSION: This is the first case report of a patient, with a history of posaconazole allergy, successfully challenged with voriconazole.

Key concepts: Posaconazole, Voriconazole, Medicine, Rash, Maculopapular rash, Dermatology, Drug eruption, Itraconazole

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Successful challenge of voriconazole in a patient with posaconazole‐associated minor drug eruption: A case report — Research Paper | ScholarLens