Evaluation Effect of Tramadol as Premedication on Ketamine in Mice

Aims: The present study was designed to investigate the effect of different doses of tramadol as a premedication on ketamine anesthesia in mice. Materials and Methods: Tramadol used in different doses ( 0, 20, 30 ) mg/kg, I.P at 20 minute before treated with ketamine (50) mg/kg, I.P. Results: significantly increased in the duration of sleep and analgesia of ketamine without effect on the time of induction in all treated groups. The Numerical Sedation Score(NSS) was increased in all treated groups with tramadol pre treatment of ketamine but this NSS were stayed in long period in group treated with tramadol and ketamine in a dose depended manner in comparison with group treated with ketamine alone. Conclusion: Thus it can conclude that the possibility of using tramadol as a premedication with ketamine general anesthesia to improve anesthesia.