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2014•Russian Journal of AllergyOpen access

Treatment of itch in allergic dermatoses

Yu. N. Perlamutrov, Kira B. Olkhovskaya

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Abstract

Pruritus is one of the most frequent symptoms in different skin diseases. Pathophysiology of pruritus has been insufficiently studied, but to this day it is considered that the main mediator of itch is histamine. Given the important role of histamine and the location of itch receptors in the superficial layers of the epidermis, the optimum is to use a topical antihistamine. The unique properties of dimethindene (Fenistil) provides rapid elimination of symptoms of itching and inflammation in allergic dermatoses.

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What this paper is about

Pruritus is one of the most frequent symptoms in different skin diseases. Pathophysiology of pruritus has been insufficiently studied, but to this day it is considered that the main mediator of itch is histamine. Given the important role of histamine and the location of itch receptors in the superficial layers of the epidermis, the optimum is to use a topical antihistamine. The unique properties of dimethindene (Fenistil) provides rapid elimination of symptoms of itching and inflammation in allergic dermatoses.

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Available abstract

Pruritus is one of the most frequent symptoms in different skin diseases. Pathophysiology of pruritus has been insufficiently studied, but to this day it is considered that the main mediator of itch is histamine. Given the important role of histamine and the location of itch receptors in the superficial layers of the epidermis, the optimum is to use a topical antihistamine. The unique properties of dimethindene (Fenistil) provides rapid elimination of symptoms of itching and inflammation in allergic dermatoses.

Key concepts: Antihistamine, Itching, Histamine, Medicine, Dermatology, Pathophysiology, Histamine H1 receptor, Histamine antagonists

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