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2020•Journal of Medical CasesOpen access

Macrophage Activation in COVID-19 Patients in Intensive Care Unit

Guylaine Labro, Louise-Marie Jandeaux, Andreea Rusu, Edouard Virot, Valentin Pointurier, Luis Pinto, Cyrille Mathien, Agathe Pruvot Debliquis, Inès Harzallah, Joy Mootien, Bernard Drénou, Khaldoun Kuteifan

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Abstract

We report six cases of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, admitted to intensive care unit (ICU), for whom bone marrow aspirate revealed hemophagocytosis. We compared their clinical presentation and laboratory findings to those that can be encountered during a hemophagocytic lymphohistiocytosis. These observations might evoke a macrophage activation mechanism different from the one encountered in the hemophagocytic lymphohistiocytosis (HLH).

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We report six cases of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, admitted to intensive care unit (ICU), for whom bone marrow aspirate revealed hemophagocytosis. We compared their clinical presentation and laboratory findings to those that can be encountered during a hemophagocytic lymphohistiocytosis. These observations might evoke a macrophage activation mechanism different from the one encountered in the hemophagocytic lymphohistiocytosis (HLH).

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Available abstract

We report six cases of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, admitted to intensive care unit (ICU), for whom bone marrow aspirate revealed hemophagocytosis. We compared their clinical presentation and laboratory findings to those that can be encountered during a hemophagocytic lymphohistiocytosis. These observations might evoke a macrophage activation mechanism different from the one encountered in the hemophagocytic lymphohistiocytosis (HLH).

Key concepts: Medicine, Hemophagocytosis, Hemophagocytic lymphohistiocytosis, Macrophage activation syndrome, Bone marrow aspirate, Intensive care unit, Coronavirus disease 2019 (COVID-19), Macrophage

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