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2020•Circulation ReportsOpen access

Evidence for Urate Uptake Through Monocarboxylate Transporter 9 Expressed in Mammalian Cells and Its Enhancement by Heat Shock

Naoyuki Otani, Yasutaka Kurata, Nani Maharani, Masanari Kuwabara, Nobuhito Ikeda, Tomomi Notsu, Peili Li, Junichiro Miake, Akio Yoshida, Hiromi Sakaguchi, Katsumi Higaki, Naoe Nakasone, Motokazu Tsuneto, Yasuaki Shirayoshi, Motoshi Ouchi, Haruaki Ninomiya, Kazuhiro Yamamoto, Naohiko Anzai, Ichiro Hisatome

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Abstract

Background:Monocarboxylate transporter 9 (MCT9), an orphan transporter member of the solute carrier family 16 (SLC16), possibly reabsorbs uric acid in the renal tubule and has been suggested by genome-wide association studies to be involved in the development of hyperuricemia and gout. In this study we investigated the mechanisms regulating the expression of human (h) MCT9, its degradation, and physiological functions.

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Background:Monocarboxylate transporter 9 (MCT9), an orphan transporter member of the solute carrier family 16 (SLC16), possibly reabsorbs uric acid in the renal tubule and has been suggested by genome-wide association studies to be involved in the development of hyperuricemia and gout. In this study we investigated the mechanisms regulating the expression of human (h) MCT9, its degradation, and physiological functions.

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Available abstract

Background:Monocarboxylate transporter 9 (MCT9), an orphan transporter member of the solute carrier family 16 (SLC16), possibly reabsorbs uric acid in the renal tubule and has been suggested by genome-wide association studies to be involved in the development of hyperuricemia and gout. In this study we investigated the mechanisms regulating the expression of human (h) MCT9, its degradation, and physiological functions.

Key concepts: Monocarboxylate transporter, Transporter, Hyperuricemia, Uric acid, Solute carrier family, Chemistry, Biochemistry, Cell biology

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