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2020•Indian Journal of Public Health Research & DevelopmentRequires access

Evaluation of Malondialdehyde, Glutathione Peroxidase and Defensin Levels in Patients with and without Periodontitis

J Hemashree, Sreedevi Dharman, Selvaraj Anon

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Abstract

Aim: Aim of the study is to estimate the levels of Malondialdehyde, glutathione peroxidase and Defensin levels on patients with and without periodontitis. Materials and Method: The levels of Malondialdehyde and Glutathione peroxidase was estimated using colorimetric estimation and Defensin was estimated using ELISA. Results: Levels of Defensin is increased in patients with periodontitis 9.18+-1.72 when compared to healthy subjects 6.22+-2.73. The mean levels of MDA is increased in patients with periodontitis 2.35+-0.32 when compared to normal patients 3.58+-0.36. The levels of Gpx is lower in patients with periodontitis 2.52+-0.58 when compared to normal patients 3.58+-0.36. The p-value was found to be significant (0.001). Conclusion: Thus, this study reveals that Malondialdehyde, Defensin and glutathione peroxidase can be considered as biomarkers in the periodontal diseases.

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Aim: Aim of the study is to estimate the levels of Malondialdehyde, glutathione peroxidase and Defensin levels on patients with and without periodontitis. Materials and Method: The levels of Malondialdehyde and Glutathione peroxidase was estimated using colorimetric estimation and Defensin was estimated using ELISA. Results: Levels of Defensin is increased in patients with periodontitis 9.18+-1.72 when compared to healthy subjects 6.22+-2.73. The mean levels of MDA is increased in patients with periodontitis 2.35+-0.32 when compared to normal patients 3.58+-0.36. The levels of Gpx is lower in patients with periodontitis 2.52+-0.58 when compared to normal patients 3.58+-0.36. The p-value was found to be significant (0.001). Conclusion: Thus, this study reveals that Malondialdehyde, Defensin and glutathione peroxidase can be considered as biomarkers in the periodontal diseases.

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Available abstract

Aim: Aim of the study is to estimate the levels of Malondialdehyde, glutathione peroxidase and Defensin levels on patients with and without periodontitis. Materials and Method: The levels of Malondialdehyde and Glutathione peroxidase was estimated using colorimetric estimation and Defensin was estimated using ELISA. Results: Levels of Defensin is increased in patients with periodontitis 9.18+-1.72 when compared to healthy subjects 6.22+-2.73. The mean levels of MDA is increased in patients with periodontitis 2.35+-0.32 when compared to normal patients 3.58+-0.36. The levels of Gpx is lower in patients with periodontitis 2.52+-0.58 when compared to normal patients 3.58+-0.36. The p-value was found to be significant (0.001). Conclusion: Thus, this study reveals that Malondialdehyde, Defensin and glutathione peroxidase can be considered as biomarkers in the periodontal diseases.

Key concepts: Malondialdehyde, Glutathione peroxidase, Periodontitis, Defensin, Peroxidase, Medicine, Internal medicine, Glutathione

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Evaluation of Malondialdehyde, Glutathione Peroxidase and Defensin Levels in Patients with and without Periodontitis — Research Paper | ScholarLens