Application of OCT in acute primary angle-closure glaucoma.

Objective To explore the change law of the retinal nerve fiber layer(RNFL) thickness in acute primary angle-closure glaucoma(APACG).Methods 26 subjects of APACG with the first acute attack(6 hours) and 30 normal controls were included in this study.The RNFL thickness was accessed by optical coherence tomography(OCT)on the 1st day when the cornea became clear and at 1 week,1 month,3 months,and 6 months after intraocular pressure(IOP) was controlled(5 times).RNFL thickness was compared between attacked eyes and normal control eyes.Results RNFL thickness on the 1st day of corneal transparency(122.14±21.37)μm was thicker than that of normal controls(P0.01).At 1 week after IOP was controlled,RNFL thickness(110.25±17.43)μm was thicker than that of normal controls(P0.05).At 1 month after IOP was controlled,RNFL thickness(103.34±15.19)μm was a little thicker than that of normal controls(P0.05),there was no significant difference.At 3 months(102.56±14.11)μm and 6 months (101.22±15.54)μm after IOP was controlled,RNFL thickness was a little thinner than that of normal control(P0.05),and there were no significant differences.Conclusion In the early period,acute rising of IOP caused edema of the retina,and RNFL became thicker.After IOP decreased to a normal range,RNFL became thinner.At 3 and 6 months after IOP was controlled,the RNFL thickness tended to be stable.