The study of relationship between cytokine IL6, IL8, IL-10 and allergic rhinitis

Objective To provide experimental evidence and guide clinical treatment by exploring the role of IL-6,IL-8,IL-10 in allergic rhinitis patients.Methods The serum samples were collected from 35 cases of normal healthy controls and 60 patients with allergic rhinitis line before and after the desensitization treatment.The serum expression levels of IL-6,IL-8,and IL-10 were detected by double antibody sandwich ELISA method.SPSS 13.0 software was used for statistical analysis.Results IL-6,IL-8 in the AR patients were with high expression compared with the control group ( t =15.213,P ＜0.01 ; t =12.231,P ＜ 0.01 ) after desensitization treatment,the expression decreased compared with the pre-treatment and there were high significant difference ( t =21.995,P ＜ 0.01 ; t =19.766,P ＜ 0.01 ) ; IL- 10 expression in the serum of patients was with lower than the control group,the difference was significant (t =7.446,P ＜ 0.01 ).With desensitization therapy,its expression was rose compared with the pre-treatment and significant difference was found ( t =10.228,P ＜ 0.01 ).Besides,IL-6 and IL-8 expressions in AR patients showed a positive correlation ( r =0.523,P ＜ 0.01 )and negative correlation with IL-10 ( r =- 0.482,P ＜ 0.01 ).Conclusion IL-6,IL-8,and IL-10 play an important role in the pathogenesis of allergic rhinitis.The corresponding cytokines or antagonists will likely become the candidate therapeutic drugs. Key words: Cytokine ;  IL-6 ;  IL-8 ;  IL-10 ;  Allergic rhinitis