2005•Zhonghua fangshexian yixue zazhiRequires access

An experimental study of the diagnosing value to nude mice model of transplanted human gastric cancer with folate-receptor MR contrast agent

Ding Jianhui, Meng-Su Zeng, Zhou Kangrong, Shen Jizhang, Chen Caizhong, Gaoren Zhong, Qiong Xue, Haiyan Gu

Abstract

目的通过探讨以叶酸介导的钆喷替酸葡甲胺(Gd-DTPA-Folate)对裸鼠瘤体信号改变的规律,评价其肿瘤靶向作用.方法将DTPA-Folate与氯化钆(GdCl3)在一定条件下等摩尔反应,过滤后得到Gd-DTPA-Folate,将5～6周龄无特定病原体(SPF)级BALB/C裸小鼠皮下接种人胃癌细胞(SGC-7901)作为动物模型;将12只荷人胃癌裸小鼠模型采用完全随机法分成实验组(6只)与对照组(6只),前者腹腔注射Gd-DTPA-Folate 0.4 ml,后者腹腔注射相同剂量并含相同Gd离子浓度的Gd-DTPA,观察注射前后2组T1WI瘤体信号改变情况.判断指标为对比信噪比(contrast noise ratio ,CNR).注射后扫描时间点选择为即刻、1、2、3、4、6、12及24 h.结果注射对比剂后1 h(q1)和2 h(q2),实验组裸鼠瘤体信号强度升高明显,与注射对比剂前比较,差异有统计学意义(以计算值CNR为判断指标:q1=5.80, q2=4.64, P值均 0.05).结论 Gd-DTPA-Folate对裸鼠胃癌模型(SGC-7901)肿瘤具有一定的靶向性。

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Key concepts: Medicine, Folate receptor, Contrast (vision), Cancer, Value (mathematics), Nude mouse, Nuclear medicine, Oncology