Diagnosing the Location of Carcinoma in situ (CIS) of the Urinary Bladder Using Pirarubicin Hydrochloride

Objectives To discuss the effect of pirarubicin hydrochloride(THP) on niveau diagnosis of bladder carcinoma in situ( CIS).Methods We dissolved 50 mg of THP in 50 ml of distilled water,and instilled the resulting solution into the urinary bladder.After 5 min,the urinary bladder is examined using a cystoscope.The study group consisted of 15 subjects.Results THP uptake was seen in 11 flat ( nontumorous) areas of the bladder mucosa in 11 patients.Of these,11 lesions in 3 patients were confirmed to be CIS.THP uptake was also seen in flat malignant lesions such as bladder cancer invasion into the prostatic urethra,and in benign lesions such as chronic cystitis and urothelial hyperplasia.Conclusions The present method can be useful to fi nd easily and macroscopically the location of flat malignant lesions such as CIS. Key words: Bladder Neoplasms; Doxorubicin