2009•Zhonghua neifenmi daixie zazhiRequires access

Musclin gene overexpression in skeletal muscle of rats with long-term high-fat diet and its correlation with insulin resistance

Lingling Cao, Jiang-xiang Xu, Zhiqiang Liu, Xia Wang

Abstract

The expression of musclin gene in skeletal muscle of rats fed with high-fat diet and its correlation to insulin resistance.diabetes mellitus and GLUT4 were explored.The results showed that musclin expressin was up-regulated(1.39±0.36 vs 0.31±0.07,P<0.01)in skeletal muscle of rats fed with high-fat diet, suggesting that this finding may be related with insulin resistance and involvement of GLUT-4 expression(1.27 4± 0.32 vs 1.84±0.24.P<0.01). Key words: Insulin resistance; Musclin; Glucose transporter 4; Gene expression

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: GLUT4, Internal medicine, Endocrinology, Insulin resistance, Skeletal muscle, Insulin, Glucose transporter, Biology