2018•International Journal of SurgeryRequires access

Research progress of miR-224 in colorectal cancer

Meiyuan Yang

Abstract

Colorectal cancer is the third most common cancer in humans and poses a serious threat to human health. MicroRNAs (miRNAs) affected the mechanism of occurrence and development of colorectal cancer.As an important member of miRNA, miR-224 modulates the migration, proliferation, metastases and drug resistance of colorectal cancer by acting on its downstream targets. The expression of miR-224 affects the prognosis of colorectal cancer. Therefore, this review summarizes the role of miR-224 and its downstream targets in colorectal cancer, it may provide a new method for diagnosis and treatment to colorectal cancer at the cellular and molecular level. Key words: Target gene repair; Colorectal neoplasms; Review; MiR-224

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Key concepts: Colorectal cancer, Medicine, Mouse model of colorectal and intestinal cancer, microRNA, Cancer, Oncology, Cancer research, Mechanism (biology)