2014•肿瘤研究与临床Requires access
Research progress of the roles of Polo-like kinase 1 in cell mitosis
Wěi Li
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Abstract
Polo-like kinase 1 (Plk1) is a serine/threonine kinase that is widely expressed in eukaryotic cells and a key regulator of the cell mitosis.During different stages of mitosis,the locations of Plk1 in cells are different,and can interaction with different substrates,thus it has many biological functions.This article focuses on the functions of Plk1 in different mitotic stages.
Key words:
Polo-like kinase 1; Mitosis; G2/M checkpoint