Diagnostic value of CD64, procalcitonin, serum amyloid A protein and C-reactive protein in acute bacterial and viral infectious diseases

Objective To evaluate the clinical diagnostic value of the combined detection of CD64, serum amyloid A protein (SAA) , procalcitonin (PCT) and C-reactive protein (CRP) for acute infectious diseases. Methods CD64, SAA, PCT and CRP were detected in 241 patients with bacterial infection, 162 patients with viral infection and 144 healthy controls, respectively. The diagnosis value of CD64, PCT, SAA and CRP were analyzed by ROC curve. Results In bacterial infection group, CD64, SAA, PCT and CRP were (17.77±6.18) MFI, (179.37±116.56) mg/L, (1.22±0.39) ng/mL and (51.03±34.34) mg/L, respectively. In viral infection group, CD64, SAA, PCT and CRP were (9.85±2.69) MFI, (122.14±101.58) mg/L, (0.13±0.08) ng/mL and (15.62±13.04) mg/L, respectively. In healthy control group, CD64, SAA, PCT and CRP were (9.35±2.16) MFI, (5.55±3.36) mg/L, (0.11±0.05) ng/mL and (3.93±2.77) ng/mL, respectively. The different levels of CD64, SAA, PCT and CRP were statistically significant in 3 groups (F=59.449, 32.710, 31.531 and 34.439, P all <0.01) . The area under ROC curve of SAA was 0.812 to diagnose acute viral infection, and the sensitivity was 0.783. The diagnostic value was better than CRP. The area under ROC curve of CD64 was 0.882 to diagnose acute bacterial infection, and the sensitivity was 0.908. The diagnostic value was better than PCT. The area under ROC curve of the four index combined detection was 0.941 to diagnose acute bacterial infection, and the sensitivity was 0.983. The area under ROC curve of the four index combined detection was 0.850 to diagnose acute viral infection, and the sensitivity was 0.800. Conclusions SAA is better than CRP in diagnosing viral infection, while CD64 is better than PCT in diagnosing the bacterial infection. To diagnose bacterial infection or viral infection, the combined detection of CD64, SAA, PCT and CRP is better than respective detection. Key words: Communicable diseases; CD64; Procalcitonin; Serum amyloid A protein; C-reactive protein