2010•国际外科学杂志Requires access

Relation between interstitial cells of cajal and slow transit constipation

Shou-yi Sun, Xiao Hu, Guo Zhang

Abstract

Interstitial cells of Cajal (ICC) is interposed between enteric neurons and smooth muscle cells in gastrointestinal muscles, it is the pacemaker cells of the gastrointestinal tract. ICC are essential for generation and regeneration of slow wave and play an important role in the regulation of gastrointestinal smooth muscle. Further study of ICC has importance in realizing the physiology of gastrointestinal motor and the mechanisms of gastrointestinal motility disease. Key words: Interstitial cells of Cajal; Slow transit constipation

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Key concepts: Interstitial cell of Cajal, Motility, Gastrointestinal tract, Enteric nervous system, Constipation, Smooth muscle, Gastrointestinal transit, Neuroscience