Progress in the pathogenesis of neonatal necrotizing enterocolitis

Neonatal necrotizing enterocolitis(NEC)is one of common gastrointestinal critical diseases in the neonatal medical center, with high morbidity and mortality.The pathophysiological mechanism of the NEC is still unclear so far.Thus, the treatment of NEC is currently mainly limited to the symptomatic treatment in clinic.In the recent years, the studies on the pathogenesis of NEC have been increasing.This artical clarified the pathogenesis of NEC in six aspects: the pathogeny of intestinal immune function, gut microbiome, oxidative stress reaction, breastfeeding, blood transfusion and inflammatory mediators, to provide a new detection in prevention, diagnosis and treatment of NEC. Key words: Neonatal necrotizing enterocolitis; Pathogenesis