Correlation analysis between islet function condition and blood pressure in obese women with the same body composition

Objective To investigate the correlation between blood pressure and islet function condition in obese women with the same body composition. Methods First 88 obese women(BMI≥25.0 kg/m2) were divided into 3 groups according to their blood pressure: normal blood pressure group, prehypertension group, and hypertension group. Then, dual energy X-ray absorptiometry(DEXA) was used to measure their fat and lean mass, and calculate indexes of body composition(the fat and lean content of the whole body, trunk and four limbs). Next we calculated the area under the curve of insulin (AUCins) and acute insulin response (AIR) phase by intravenous glucose tolerance test(IVGTT). HOMA was used to calculate homeostasis model β-cell function index(HOMA2-%B), homeastasis model insulin sensitivity index (HOMA2-%S)and homeostasis model insulin resistance index (HOMA2-IR). Next, we built data models of hypertension and prehypertension, and used Binary Logistic regression to analyse risk factors. Results There was no significant difference either among age, FPG, BMI, WHR and indexes of body composition of these three groups or among the HOMA2-%B, AUCins, and AIR. When increasing of blood pressure, 2 h PG, IVGTT ins0, TG, HOMA2-IR increased(P<0.05), but HOMA2-%S decreased (P<0.05), SBP showed a positive correlation with 2 h PG, TC, TG, IVGGT ins0, and HOMA2-IR, but a negative correlation with HOMA2-%S. DBP showed a positive correlation with 2 h PG, TG, and negative correlation with HOMA2-%S. Results of Logistic regression analysis showed that 2 h PG, HOMA2-IR, TG were in the equation in both models. Conclusion Insulin resistance is an important related risk factor for hypertension and even prehypertension in obese women with the same body composition. Key words: Obesity; Body composition; Intravenous glucose tolerance test; Islet function condition; Blood pressure