Tumor necrosis factor-related apoptosis-inducing ligand and its receptors in lung cancer therapy

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a newly discovered apoptosis-inducing ligand that can induce apoptosis of cancer cells, but not of normal cells, through the activation of multiple signaling transduction pathways. By sensitizing lung cancer cells but not normal cells to apoptosis,TRAIL may become a new strategy for the treatment of lung cancer. Key words: Lung neoplasms ;  TNF-related apoptosis-inducing ligand ;  Apoptosis ;