2006•Int J Radiat Med Nuel MedRequires access

γ-H2AX assay and its prospect of detecting DNA double-strand breaks caused by ionizing radiation

由莉, 赵永成

Abstract

近几年的研究表明,组蛋白H2AX在DNA损伤修复、细胞周期检查点调控、基因组稳定的维持和肿瘤抑制中起着重要作用,而且在放射生物学中具有应用前景.磷酸化的组蛋白H2AX(γ-H2AX)对DNA双链断裂快速敏感的反应使其成为DNA双链损伤的标志.γ-H2AX分析也将在监测电离辐射尤其是低剂量电离辐射所致的DNA双链损伤中拥有广阔的应用前景。

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Key concepts: Ionizing radiation, Double strand, DNA, DNA damage, Physics, Biology, Genetics, Irradiation