2011•国际外科学杂志Requires access
Research progress of heparanase in malignant tumor
Guo-li Chen, Lie Wang
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Abstract
Heparanase, an endo- β- D- glucuronidase, that cleaves heparan sulfate chains in heparan sulfate proteoglycans, has recently been found in mammalian. It may play a key role in tumor progression and metastasis. Here we disscuss its molecular structure, biochemical properties, expression in malignant tumor,mechanism in accelerating tumor metastasis and application in heparanase inhibitor.
Key words:
Heparanase; Tumor metastasis; Heparanase inhibitor