The influence of laparoscopic cholecystectomy and open cholecystectomy on serum C reactive protein, IL-6,TNF-α in elderly patients

Objective To investigate the influence of laparoscopic cholecystectomy (LC) and open cholecystectomy (OC) on serum C reactive protein,IL-6,TNF-α in elderly patients.Methods 100 elderly patients with calculous cholecystitis were randomly divided into LC group and OC group,with 50 cases in each group.All of the patients were phlebotomized 2 ml fasting elbow venous blood 1 day before surgery,24,48,72 hours after surgery.The levels of serum C reactive protein,IL-6,TNF-α were detected by enzyme linked immunosorbent assay (ELISA).Results The levels of C reactive protein,Ⅱ-6,TNF-α significantly increased 24,48,72 h after surgery in both two groups (P ＜ 0.01).The levels of C reactive protein,IL-6,TNF-α in LC group 24,48,72 h after surgery were significantly lower than those in OC group (P ＜ 0.01).The level of C reactive protein in LC group 72 h after surgery returned back to the level on the first day before surgery (P ＞ 0.05),with a faster decline speed (P ＜ 0.01).Conclusion Laparoscopic cholecystectomy and open cholecystectomy would both lead to the raise of serum C reactive protein,IL-6,TNF-α.Compared with open cholecystectomy,laparoscopic cholecystectomy has little influence on immune function in elderly patients after surgery. Key words: Elderly patients;  Cholecystectomy;  C reactive protein;  Interleukin-6;  Tumour necrosis factor