Clinical significance of preoperative measurement of serum human epididymis protein 4, CA125 and CA19-9 in endometrial cancer patients

Preoperative serum specimens were collected from 249 endometrial cancers and 99 uterine leiomyomas and their concentrations of human epididymis protein 4(HE4), CA125 and CA19-9 were detected. The indices of diagnostic evaluation were calculated. Preoperative serum concentrations of HE4, CA125 and CA19-9 in endometrial carcinoma group were significantly higher than those of control group. The areas under curve of HE4, CA125 and CA19-9 were 0.736, 0.615 and 0.661 respectively and that of combined markers was 0.774. At a 90% specificity, the sensitivities for HE4, CA125, CA19-9 were 55.0%, 26.9% and 30.1% while that of combined markers was 56.2%. HE4 is an ideal tumor marker for endometrial cancer and combined detection improves diagnostic rate. Key words: Endometrial cancer; Tumor marker