Application and development of viral vectors in neural stem cells

The viral vector is an ideal tool for cell genetic modification in biomedical research and gene therapy. It is one of the hotspots in the research of genetic engineering. The vector is a transportation tool for inserting and transferring the target gene into the host cell. The virus vector could cure incurable diseases and explore the safety of the viral vector and toxic problems. At present, more researches are retrovirus, lentivirus, adenovirus, adeno-associated virus vector system. In this review, application and development of the above four viral vectors in neural stem cell were reviewed. Key words: Viral vector; Gene therapy; Neural stem cells; Application