Effects of Dexmedetomidine infusion at different doses on anesthesia recovery period in endoscopic sinus surgery

Objective To investigate the effects of continuous Dexmedetomidine infusion given at different doses on anesthesia recovery period in endoscopic sinus surgery. Methods Between August 2014 to June 2015, 60 adult patients undergoing elective endoscopic sinus surgery under general anesthesia in our hospital were randomized to 0.2 μg·kg-1·h-1 Dexmedetomidine infusion group (group D1) , 0.5 μg·kg-1·h-1 Dexmedetomidine infusion group (group D2) and control group (group C) , with 20 patients in each group. We recorded the time of anesthesia recovery, changes in hemodynamics, SAS score and EA score changes, and incidence of adverse events in all groups. Results In Group C, the values of SBP and DBP during extubation (T1) and at 10 min after extubation (T2) were significantly higher than that before the end of surgery (T0) (both P 0.05). At extubation, patients in group D2 had lower SAS and EA scores than those in groups C and D1 (P<0.05). Patients in group D2 had less nausea, vomiting and chills compared with those in groups C and D1 (P<P <0.05). Conclusion Continuous Dexmedetomidine infusion given at 0.5 μg·kg-1 · h-1 during endoscopic sinus surgery helps maintain steady hemodynamics during anesthesia recovery period, reduce patient agitation, and does do not prolong the length of recovery period. Key words: Dexmedetomidine; Intravenous infusion; Endoscopic sinus surgery; Anesthesia recovery period