Effects and clinical significance of Songlingxuemaikang on blood pressure variability in patients with mild essential hypertension

Objective To investigate the effect and significance of Songlingxuemaikang capsule on blood pressure variability in patients with mild essential hypertension. Methods Ninety untreated patients with mild essential hypertension were randomly divided into two groups at the ratio of 2∶1, the Songlingxuemaikang group(n=60)and the losartan potassium group(n=30). The blood pressure, the ambulatory blood pressure and the variability of blood pressure in the two groups were compared before and after treatment. Results After 12 weeks of treatment, the 24 h systolic blood pressure variability(SBPV), 24 h diastolic blood pressure variability(DBPV)and daytime DBPV were significantly decreased in Songlingxuexmaigkang group [(20.3±5.1)mmHg vs.(28.4±5.5)mmHg, (10.1±3.0)mmHg vs.(14.8±4.9)mmHg, (10.1±3.4)mmHg vs.(13.2±3.4)mmHg, all P 0.05). Conclusions Songlingxuexmaigkang can significantly reduce the blood pressure variability and blood pressure in patients with mild essential hypertension at the same time. Key words: Songlingxuemaikang; Blood pressure; Variability