Effect of dexmedetomidine for blood pressure, heart rate and SpO2 levels during anesthesia inquiry in elderly hypertensive patients

Objective To explore the effect of dexmedetomidine(DEX) for blood pressure, heart rate(HR) and SpO2 levels during anesthesia inquiry in elderly hypertensive(HBP) patients. Methods 96 cases with HBP accepted surgery were selected, and were randomly divided into the observation group and the control group, each group in 48 cases, The patients in the observation group continuous pumped into the 4μg/mL of DEX during surgery, while the control group continuous pumped into 0.9% sodium chloride solution during surgery.Heart rate(HR), systolic blood pressure(SBP), diastolic blood pressure(DBP), pulse oxygen saturation(SpO2) of the two groups after room entrance(T0), after DEX infusion(T1), before intubation(T2), after 2min intubation(T3) and 10 min(T4) after intubation were recorded and compared, extubated time, spontaneous breathing recovery time, call time to eye opening and hospitalization time and the incidence of adverse reactions in two groups were recorded. Results The difference of HR SBP, DBP and SpO2 at T0 and T4 between the two groups was not statistically significant(all P>0.05); HR, SBP and DBP were significantly lower in the observation group than those in the control group at T1, T2, T3(all P 0.05). Conclusion Continuous pumped DEX has a significant sedative effect in elderly HBP patients during surgery, and does not produce respiratory depression, can help elderly patients with HBP smoothly pass the perioperative period. Key words: Hypertension; Hemodynamics; Dexmedetomidine; Aged