Effects of lipoicacid on renal function in patients with cardiac valve replacement

Objective To investigate the effect of lipoicacid on renal function in patients with cardiac valve replacement.Methods Thirty patients scheduled to receive cardiac valve replacement were randomly divided into lipoicacid group(group L,n =15) and control group(group C,n =15).After tracheal intubation,lipoicacid 50 mg/kg was administered intravenously in group L and lipoicacid was infused at 50 mg/kg on the first 5 days after operation,while in group C only equivalent normal saline was administed.Blood samples were taken before operation (T0),on the 1st(T1),3rd (T3),5th (T5),and 7th(T7) day after operation for measurement of serum urea nitrogen(BUN),creatinine(Cr),β2-microglobulin(β2-MG).Results BUN,Cr and serum β2-MG levels increased significantly after operation at T1 and T3,as compared with the baseline values (T0) in both groups,but the levels in group L were significantly lower than those in group C at the same stage (P ＜ 0.01).Conclusions Applying lipoicacid at the perioperative stage has protective effects on renal function in patients with cardiac valve replacement. Key words: Cardiopulmonary bypass; Renal function test; Lipoicacid