2013•Zhonghua neifenmi daixie zazhiRequires access

Osteocyte — A new target for the treatment of osteoporosis

Xi‐Yu Wu, Xianping Wu, Ling‐Qing Yuan

Abstract

The osteocyte has been found to be an orchestrator of bone remodeling.The damage of bone leads to osteocyte apoptosis.Sclerostin secreted by osteocyte causes feedback inhibition of bone formation,so inhibition of sclerostin expression has become a new target of treatment for osteoporosis.It seems resonable to direct clinical practise and treatment of metabolic bone diseases through understanding the function of osteocyte in the process of bone remodeling. Key words: Osteocyte; Osteocyte death ; Bone remodeling; Sclerostin; Osteoporosis

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Key concepts: Osteocyte, Sclerostin, Osteoporosis, Bone remodeling, Internal medicine, Endocrinology, Medicine, Chemistry