2016•Chinese Journal of DermatologyRequires access
In vitro antibacterial activity of fusidic acid cream against Staphylococcus epipermidis and Propionibacterium acnes isolates from acne vulgaris lesions
Gao ShiYan, LU Yong-hong, Tao Chen, Shanshan Wang, He LiSha, Shan YuTing, Zhou Pei-mei, Qingbiao Wa, Bo Wu, Liping Lin, Qianming Chen, Yong Bao, Yin YaFei, Lu Ling
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Abstract
Objective
To investigate the in vitro antibacterial activity of fusidic acid cream against Staphylococcus epipermidis and Propionibacterium acnes isolates from acne vulgaris lesions.
Methods
The agar diffusion method was used to evaluate the antibacterial activity of fusidic acid cream and mupirocin ointment against S. epipermidis and P. acnes isolates from acne vulgaris lesions in vitro. Inhibition zone diameters were measured and compared between the two topical drugs.
Results
A significant difference was observed between the fusidic acid cream and mupirocm ointment in the inhibition zone diameters for P. acnes (18.15 ± 3.24 vs. 3.00 ± 0.00 mm, t= 24.27, P 0.05) .
Conclusion
Fusidic acid cream displays strong in vitro antibacterial activity against S. epidermidis and P. acnes isolates from acne vulgaris lesions.
Key words:
Acne vulgaris; Fusidic acid; Propionibacterium acnes; Staphylococcus epidermidis; Microbial sensitivity tests