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2013•Int Rev OphthalmolRequires access

Research progress of TGF-β/Smad signaling pathway in posterior capsule opacification

Jun Li, Yawen Guo, Xin Tang

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Abstract

Posterior capsule opacification (PCO) is the frequent complication after cataract surgery.Transforming growth factor-β (TGF-β) is the important growth factor to modulate the transdifferentiation and formation of extracellular cell matrix (ECM) of cells.TGF-β modulates the proliferation,epithelial-mesenchymal transition and the formation of ECM by Smad signaling pathway.The research progress of TGF-β/Smad signaling pathway in PCO is reviewed in this article. Key words: TGF-β ;  Smad ;  signaling pathway ;  epithelial-mesenchymal transition

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What this paper is about

Posterior capsule opacification (PCO) is the frequent complication after cataract surgery.Transforming growth factor-β (TGF-β) is the important growth factor to modulate the transdifferentiation and formation of extracellular cell matrix (ECM) of cells.TGF-β modulates the proliferation,epithelial-mesenchymal transition and the formation of ECM by Smad signaling pathway.The research progress of TGF-β/Smad signaling pathway in PCO is reviewed in this article. Key words: TGF-β ;  Smad ;  signaling pathway ;  epithelial-mesenchymal transition

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Available abstract

Posterior capsule opacification (PCO) is the frequent complication after cataract surgery.Transforming growth factor-β (TGF-β) is the important growth factor to modulate the transdifferentiation and formation of extracellular cell matrix (ECM) of cells.TGF-β modulates the proliferation,epithelial-mesenchymal transition and the formation of ECM by Smad signaling pathway.The research progress of TGF-β/Smad signaling pathway in PCO is reviewed in this article. Key words: TGF-β ;  Smad ;  signaling pathway ;  epithelial-mesenchymal transition

Key concepts: SMAD, Transdifferentiation, Transforming growth factor, Extracellular matrix, Signal transduction, Epithelial–mesenchymal transition, Cell biology, Transforming growth factor beta

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