Sodium valproate in clinical examination for different leukocyte toxicity in patients with the type of seizure characteristics

Objective To investigate the clinical tests of white blood cell of different types of epilepsy patients who treated with valproate, to analyse the rules and characteristics of hematological toxicity, and to explore its possible mechanism. Methods Sixty-one patients with epilepsy, taken fasting peripheral blood immediately after the use of valproate monotherapy, and peripheral hemogram measurement was detected by SYSMEX automatic blood cell analyzer, including red blood cell, hemoglobin, white blood cell, platelet count. Results There were various manifestations of hematological toxicity of sixty-one patients with epilepsy, The number of white blood cell in fifty-five patients decreased among them, the number of red blood cell in three patients decreased, and the platelet count decreased significantly in ten patients.After being treated with sodium valproate.After using valproate treatment, white blood cell count reduced in all types, the differences were statistically significant.But there was no statistical difference among the types of white blood cell. Conclusions Sodium valproate can cause leucocyte count, red blood cell count and platelet levels decrease in some patients with partial epilepsy and the decrease of white blood cells count has nothing to do with different types of eplepsy. Key words: Epilepsy; Valproic acid; Ieukocytes