2015•Zhonghua shiyan waike zazhiRequires access
Comparative study of different time sevoflurane on rocuronium effect of muscle relaxants in patients undergoing operation with general anesthesia
Xiaochong Fan, Minyu Ma, Shengkai Gong, Wei Zhang, Chen Huang
Open publisher page 0 citations
Abstract
Objective
To observe the influence of different time sevoflurane on rocuronium effect of muscle relaxants in patients with general anesthesia.
Methods
Seventy-two ASAⅠ-Ⅱfemale patients undergoing breast operation with general anesthesia were randomly divided into four groups(n= 18 each),inhaled 0 min sevoflurane group(S0 group),inhaled 20 min sevoflurane group (S20 group), inhaled 45 min sevoflurane group(S45 group), propofol group(P group). A bolus of rocuronium 0. 6 mg/kg was given during maintenance of anesthesia. Neuromuscular function was monitored using train of four(TOF) response measured by accelemgraphy. The onset time, peak time, clinical role time, recovery index, response in vivo time,and the time of TOF recovery to 90% were recorded.
Results
The onset time and peak time showed no significant difference(P> 0. 05) between S0 group and P group.Twenty min after inhalation of sevoflurane, with the inhalation time over, the onset time was gradually shortened:S0[(106±56)s]> S20[(77±23) s]> S45[(63±22) s](P< 0. 05); peak time was gradually extended:S0[(23. 1±6. 1)min]< S20[(27. 7±4. 2)min]< S45[(34. 7±4. 1) min](P< 0. 05); clinical role time was gradually extended:S0[(34. 2±4. 3)min] < S20[(38. 7±2. 3) min]<S45[(47. 9±3. 8) min](P<0. 05); The recovery index was extended, P [(10. 6±2. 2) min]<S0[(14. 0±6. 7) min], and S20[(15. 1±1. 9) min]< S45[(23. 6±3. 9) min] (P<0. 05); The TOF90% recovery time was extended: P[(52. 0±3. 8) min]< S0[(62. 7±3. 8) min], and S20[(63. 4±3. 6) min]< S45[(82. 4±4. 2) min](P< 0. 05); The response in vivo time was gradually extended:P[(43. 3±3. 4) min]< S0[(49. 9±4. 9) min]< S20[(54. 8±4. 7) min]< S45[(75. 2±3. 5) min](P< 0. 05).
Conclusion
Sevoflurane can enhance the effects of rocuronium time-dependently. The dose of rocuronium should be reduced gradually with inhaled sevoflurane time over.
Key words:
Sevoflurane; Rocuronium; Androstanols; Dose-effect relationship,drug; Drug interaction