Clinical study of 99Tcm-N-DBODC5 as a novel myocardial perfusion imaging agent for the diagnosis of coronary artery disease

Objective To investigate the clinical value of 99Tcm-(bis(dimethoxypropylphosphinoethyl)-ethoxyethylamine)-(bis(N-ethoxyethyl)-dithiocarbamato nitride (99Tcm-N-DBODC5) for the detection of coronary artery disease (CAD).Methods From October 2010 to October 2012,46 patients with suspected CAD (31 males,15 females; average age:60 years) were recruited.They all underwent stressrest MPI using both 99Tcm-N-DBODC5 and 99Tcm-MIBI within l week.CAG was carried out within 1 month after MPI and chosen as the gold standard.The diagnostic accordance rate between MPI and CAG were analyzed using Kappa test.The diagnostic efficiency of 99Tcm-N-DBODC5 and 99Tcm-MIBI MPI was compared byx2 test.Results Among the 46 patients,29 were positive and 17 were negative for CAD by CAG.The sensitivity and specificity in the detection of CAD were 86％ (25/29) and 65％ (11/17) for 99Tcm-MIBI MPI,86％ (25/29) and 88％ (15/17) for 99Tcm-N-DBODC5 MPI (x2=2.62,P＞0.05),respectively.Among the 138 vessels,48 were positive and 90 were negative on CAG.The vessel-based sensitivity,specificity and accuracy for the detection of stenosis were not significantly different between 99Tcm-N-DBODC5 and 99Tcm-MIBI (x2=3.79,all P＞0.05).The accordance between 99Tcm-N-DBODC5 MPI and angiography was very good (Kappa=0.73) and moderate for 99Tcm-MIBI MPI (Kappa=0.52).Conclusion 99Tcm-N-DBODC5 might have a potential role as a MPI agent for the diagnosis of CAD. Key words: Coronary disease ;  Tomography, emission-computed, single-photon; DBODC5 ;  MIBI