Pathological changes in thrombophilia with poor pregnancy outcomes

Pregnancy is a physiological prothrombotic state. Genetic and acquired thrombophilia increases the risk of maternal thrombophilia. Thrombophilia is not yet established as a cause of the placenta-mediated pregnancy complications, although the association between thrombophilia and placenta-mediated pregnancy complications is demonstrated. Maternal thrombophilia do not have a characteristic placental lesions. Future study on the relationship of abnormal placental pathology of poor pregnancy outcomes and thrombophilia should be considered. Key words: Thrombophilia; Pregnancy complications; Placenta