Therapeutic prospects of recombinant human growth hormone combined with estrogen on Turner syndrome

Turner syndrome is a relatively common chromosomal disorder, caused by complete or partial X monosomy deletion, or structure abnormalities. Short stature and gonadal dysgenesis are two major clinical features of the syndrome, with many organs and tissues being affected. Recombinant human growth hormone (rhGH) and estrogen are applied in improving short stature and gonadal dysgenesis respectively, and widely used in clinical practice. In recent years, studies showed that rhGH combined with low-dose estrogen could be used to treat Turner syndrome. Key words: Turner syndrome; Recombinant human growth hormone; Estrogen