Clinical observation on different doses of dexmedetomidine applied in laparoscopic gynecological surgery under the supervision of bispectral index

Objective To investigate the efficacy of different doses of dexmedetomidine (DEX) for the laparoscopic gynecological surgery.Methods In the study,120 patients scheduled for elective laparoscopic gynecological surgery in our hospital were randomly divided into three groups:group A (10 ml normal saline),group B (0.5 μ g/kg DEX) and group C (1.0 μ g/kg DEX).Mean artery pressure (MAP),heart rate (HR),the doses of remifentanil and the amount of adverse reactions were recorded before being given dexmedetomidine infusion (T0),immediately before tracheal intubation (T1),before and after skin incision (T2-3),at the end of surgery (T4) and after tracheal intubation(T5),and then analyze if there were any significant differences.Results MAP and HR in three groups at the time T2,T3,T4 and T5 were higher than those at the time T1 (P ＜ 0.05).But the MAP and HR in group A at the time T2,T3,T4 and T5 were also higher than those at the time T0 (P ＜ 0.05).The MAP and HR in group B at the time T2,T3,T4 and T5 were substantially equal to those in the time T0.But MAP and HR in group C at the time T2,T3,T4 and T5 were lower than those at the time T0 (P ＜ 0.05).The doses of remifentanil used in B and C groups were lower than those in group A (P ＜ 0.05),but there was no significant different between the doses of remifentanil used in group B and C (P ＞ 0.05).The incidence of cough,dysphonia,chill and vomit in group B and C were lower than those in group A,and the incidence of cough,dysphonia,chill and vomit in group C were also lower than those in group B (P ＜ 0.05).Conclusion DEX could maintain hemodynamic stability,and reduce the using of hardstuff and the incidence of adverse events in surgical. Key words: Dexmedetomidine;  Mean artery pressure;  Heart rate;  Adverse reaction