The value of combined detection of biomarkers in the early diagnosis and treatment of breast cancer

Objective To explore the value of combined detection of CA153,TSGF,CA125 and CEA both in nipple discharge and serum in the early diagnosis and treatment of breast cancer.Methods The serum and nipple discharge from 43cases of breast cancer and 136 cases of benign tumour was collected and tumor markers of CA153,TSGF,CA125 and CEA were detected.Results The nipple discharge and serum levels of CA153,TSGF,CA125 and CEA in bresat cancer patients were significantly higher than those in benign disease and normal women(P＜0.01).The levels of the four tumor markes had a positive correlation with Ki-67,gread,lymph node metastas and tumor recurrence (P＜0.05),and negative correlation with the level of ER and PR (P＜0.05).The sensitivity of the four markes in combination was 97.67％ and specificity was99.03％.Conclusion The dynamic combined detection of CA153,TSGF,CA125 and CEA both in nipple discharge and serum are benefit to early diagnosis and interference and better prewarning markers for monitoring their recurrence and metastasis of breast cancer. Key words: Breast cancer;  Nipple discharge;  Tumor marker;  Diagnosis, differential diagnosis