Suppressor of cytokine signaling-1 and lung diseases

Suppressor of cytokine signaling-1 (SOCS1) is a negative feedback regulator of cytokine signaling,such as interferon,interleukin-4.SOCS1 is regulated on transcription,translation and protein level.Appropriate SOCS1 expression can attenuate the inflammation in asthma,while inappropriate SOCS1 expression may increase the morbidity of asthma.SOCS1 can prevent lethal inflammation in lung infection,while it can also compromise pathogen eradication.SOCS1 mediates the interleukin-6 cyto-protection in hyperoxic acute lung injury.Idiopathic lung fibrosis and aberrant collagen production may be linked to diminished SOCS1 expression,and SOCS1 can suppress the lung fibrosis induced by bleomycin.In conclusion,SOCS1 plays an important role in many lung diseases,but the panorama and significance of SOCS1 regulation still remain to be elucidated. Key words: Suppressor of cytokine signaling- 1 ;  Signal transduction;  Lung diseases