Amniotic fluid karyotype and clinical indications analysis in 1659 cases

Objective To investigate the value of different prenatal diagnostic indications in screening fetal chromosomal abnormalities during the second trimester. Methods Amniotic fluid karyotype in 1659 pregnant women were analyzed retrospectively. According to different indications, two types of prenatal diagnostic indications but only one was used to calculate the incidence of fetal chromosomal abnormalities. Results In 1659 cases, 80 cases were positive for chromosomal abnormalities (4.82%), Prenatal diagnosis refers to the highest detection rate of adverse pregnancy history syndrome chromosomal abnormalities (7.41%), followed by ultrasound abnormalities (6%) and the elderly (4.67%); two kinds of indications for prenatal diagnosis were higher than that of only one indication. Chromosome abnormalities were the most common in trisomy 21(47.5%), of which amniotic fluid abnormalities were the most common in older women (61.8%), followed by X chromosome abnormalities (20%). Conclusion Trisomy 21 and X chromosome abnormalities are common chromosomal abnormalities in prenatal diagnosis of amniotic fluid. Analysis of multiple prenatal diagnostic indications can improve the detection rate of chromosomal abnormalities. Key words: Amniotic fluid karyotype analysis; Karyotype abnormal; Prenatal diagnosis