The value of high resolution diffusion-weighted imaging in adolescent primary osteosarcoma

Objective To evaluate the diagnostic value of high resolution diffusion weighted imaging (RESOLVE-DWI) in adolescent primary osteosarcoma, and to compare the difference of image quality and apparent diffusion coefficient (ADC) value with conventional DWI echo planar imaging (EPI)-DWI. Methods Siemens Skyra 3.0T superconducting magnetic resonance imaging (MRI) scanner was used to collect MRI images of 30 patients suspected to be adolescent primary osteosarcoma. RESOLVE-DWI EPI-DWI was performed. Meanwhile, the signal-to-noise (SNR) and ADC values of osteosarcoma tissues were measured and compared with the final pathological examination results. The image quality scores, SNR and ADC values of different diffusion weighted imaging sequences were tested by two independent samples t test. Results The overall quality of RESOLVE-DWI sequence images was significantly better than that of EPI-DWI diffusion images, including 23 patients with RESOLVE-DWI scores ≥ 4 scored and 1 patients with EPI-DWI scores≥ 4, with significant difference(P 0.05). The average SNR of RESOLVE-DWI group was significantly higher than that of EPI-DWI sequence group (3.77±0.51 vs 1.97±0.23, P<0.01). Conclusions RESOLVE-DWI can improve the image quality and the SNR, and the ADC value of osteosarcoma tissue is not affected. It can provide more valuable diagnostic efficacy for the diagnosis of primary osteosarcoma in adolescents, and can be routinely used in the scanning of primary osteosarcoma in adolescents. Key words: Osteosarcoma/DI; Diffusion magnetic resonance imaging; Adolescent