Effects of rituximab combined with CHOP scheme and single use of CHOP scheme on diffuse large B-cell lymphoma

Objective To compare the effects of rituximab combined with CHOP scheme and single use of CHOP scheme on patients with diffuse large B-cell lymphoma. Methods Thirty-four patients with diffuse large B-cell lymphoma in traditional Chinese medicine hospital of Rizhao treated with rituximab combined with CHOP scheme were selected as R-CHOP group, and 32 patients with diffuse large B-cell lymphoma treated with single use of CHOP scheme were selected as CHOP group, the treatment course was 4 weeks. The clinical effects were observed at the end of treatment, and the long-term effects were observed during the 12 -24 months after operation. Results The total effective rate of RCHOP group was higher than that of CHOP group. There was no significant difference in the complete response rate between the two groups. The partial remission rate was significantly higher in R-CHOP group than that in CHOP group（ P = 0. 032 ）. The long-term effect of R-CHOP group was superior to that of CHOP group, there was significant difference （P = 0. 026） between the two groups. Conclusions The effect of rituximab combined with CHOP scheme on diffuse large B-cell lymphoma is good, and the longterm survival rate is high. Key words: Rituximab;  CHOP scheme;  Diffuse large B-cell lymphoma