Precise treatment of intrahepatic cholangiocarcinoma

Although surgical resection is currently recognized as the only effective treatment for intrahepatic cholangiocarcinoma (ICC), it is extremely difficult to diagnose because there are no obvious clinical symptoms at the early stage. Patients are often diagnosed at the advanced stage and the lesion cannot be resected which leads to limited systemic chemotherapy. So the mortality is still high. Accurate treatment is a hot topic in the medical field, and more and more attentions have been paid to enhance the treatments of patients. This article reviewed the issues related to surgical treatment, chemotherapy, molecular targeted therapy, and immunotherapy in patients with ICC, and focuses on the latest progress of molecular targeted therapy. Key words: Bile duct neoplasms; Intrahepatic cholangiocarcinoma; Precise treatment; Molecular targeted therapy