2013•中国医师杂志Requires access
Anticancer activity of glycyrrhetinic acid-fluorouracil compound in human hepatoma Bel-7402 cell lines
Mourboul Ablise, Yongbo Wang, XU Fang-ye, Gao Miao-miao, Xuchao Yang
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Abstract
Objective To investigate the in vitro anticancer activity of glycyrrhetinic acid-fluorouracil compound (GA-Fu).Methods The human Bel-7402 hepatoma cell lines were treated with GA-Fu compound,the cell proliferation capability was determined by methyl thiazolyl diphenyl-tetrazolium bromide (MTT) method.Normal chang liver cells were used to test its cytotoxicity.The data were compared with those of 5-fluorouracil (5-Fu) anticancer drug.Results Compound GA-Fu showed less cytotoxicity in chang liver normal cells (lower than 5-Fu,P ＜ 0.05).However,a significant inhibitory activity towards human Bel-7402 cancer cell proliferation,the inhibitory activity was higher than those of 5-Fu at all the concentrations (P ＜ 0.05).Conclusions The combination of glycyrrhetinic acid with 5-Fuorouracil might increase its anticancer activity and decrease the cytotoxicity in notmal cells.It might produce synergic anticancer property and chemotherapy sensitizing effect.The results may provide an initial base for pharmacological screening of new liver-targeting anticancer agent from glycyrrhetinic acid-fluorouracil compounds.
Key words:
Glycyrrhetinic acid/therapeutic use; Fluorouracil/therapeutic use; Tumor cells, cultured; Liver neoplasms/pathology; Antineoplastic agents/pharmacology