The influence of sometostatin on TNF-α in patients with severe acute pancreatitis

Objective To explore the clinical effect of sometostatin in the treatment of severe acute pancreatitis and its influence on the level of TNF-α.Methods 68 cases with severe acute pancreatitis were randomly divided into two groups,34 cases in the control group were received general treatment,34 cases in the observation group were given sometostatin on the basi of general treatment for 5 ～ 7 days.The clinical effects and clinical indexes were observed and compared between the two groups.Results After treatment for 3 days,the level of TNF-α in the observation group was significantly lower than that in the control group( P ＜0.05 ),and the observation group patients recovered rapidly.The recovery time of blood amylase and intestinal function,hospital stay days,incidence of complications and mortality in the observation group were significantly shorter than those in the control group ( P ＜ 0.05 ).Conclusion Sometostatin is effective for treatment of severe acute pancreatitis,can decrease the level of TNF-α significantly,shorten disease course and improve the prognosis,which is good for clinical application. Key words: Pancreatitis;  Sometostatin;  TNF-α