2006International journal of pediatricsRequires access

Eotaxin and CCR3 in Bronchial Asthma

Jing Li, 李玉琴

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Abstract

嗜酸性细胞(EOS)是支气管哮喘(简称哮喘)炎症发生发展过程中一种效应细胞,EOS特异性趋化因子eotaxin和它的惟一受体--趋化因子受体3(CCR3)结合,能特异性地趋化、聚集和激活EOS,从而产生气道炎症和气道高反应性,通过对eotaxin及CCR3的深入研究,有可能进一步揭示哮喘的发病机制及对哮喘的治疗提供新的思路.该文就eotaxin及CCR3的相关进展作一综述。

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嗜酸性细胞(EOS)是支气管哮喘(简称哮喘)炎症发生发展过程中一种效应细胞,EOS特异性趋化因子eotaxin和它的惟一受体--趋化因子受体3(CCR3)结合,能特异性地趋化、聚集和激活EOS,从而产生气道炎症和气道高反应性,通过对eotaxin及CCR3的深入研究,有可能进一步揭示哮喘的发病机制及对哮喘的治疗提供新的思路.该文就eotaxin及CCR3的相关进展作一综述。

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Available abstract

嗜酸性细胞(EOS)是支气管哮喘(简称哮喘)炎症发生发展过程中一种效应细胞,EOS特异性趋化因子eotaxin和它的惟一受体--趋化因子受体3(CCR3)结合,能特异性地趋化、聚集和激活EOS,从而产生气道炎症和气道高反应性,通过对eotaxin及CCR3的深入研究,有可能进一步揭示哮喘的发病机制及对哮喘的治疗提供新的思路.该文就eotaxin及CCR3的相关进展作一综述。

Key concepts: Medicine, Eotaxin, CCR3, Asthma, Immunology, Eosinophil, Chemokine, Inflammation

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