Research progress of relationship between CXC chemokine ligand 3 and related diseases

CXC chemokine ligand (CXCL)3 is one of low relative molecular mass bioactive proteins, secreted by various kinds of cells. CXCL3 plays a pivotal role in the occurrence and development of pregnancy-associated diseases, tumors, cardiovascular diseases, and lung disorders which may be associated with its participation in the regulation of cell migration, cell invasion, vasculogenesis and so on by recruiting and activating different kinds of cells which express CXC chemokine receptor (CXCR)1/2. Blocking CXCL3 or CXCR1/2 signal transduction pathways could inhibit such pathophysiological processes as cell migration, cell invasion, angiogenesis, tumorigenesis and fibration and may be the potential targets in the prevention and treatment of multiple diseases. Therefore, this paper reviews the latest research progresses of the relationship between CXCL3 and pregnancy-associated diseases, tumors, cardiovascular diseases, and lung disorders, with the aim to reveal the concrete functions of CXCL3 in the pathogenesis of these disorders and to provide a basis for adopting new diagnosis strategies and molecular targeted therapy for these diseases. Key words: Chemokine CXCL3; Receptors, CXCR1; Receptors, CXCR2; Pathogenesis; Neovascularization, pathologic; Molecular targeted therapy; Pregnancy complications