2012•Int J ImmunolRequires access

O6-Methylguanine DNA methyltransferase protein expression and TMZ resistance in patients with glioblastoma multiforme

Enhong Shi

Abstract

Glioblastoma multiforme (GBM) is one of the most frequently occurring tumors in the central nervous system and the most malignant tumor among gliomas.Temozolomide is a newly alkylating oral drug on the treatment of glioblastoma multiforme.Some studies indicated that protein expression of O6-methylguanine-DNA-methyltransferase (MGMT) is the most important determinant of TMZ resistance.Here,the relationship of MGMT expression with TMZ resistance in glioblastoma multiforme patients will be reviewed. Key words: Glioblastoma multiforme; Temozolomide; O6-methylgu-anine-DNA-methyltransferase

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Key concepts: Temozolomide, Glioblastoma, Methyltransferase, O-6-methylguanine-DNA methyltransferase, DNA methyltransferase, Cancer research, Glioma, Drug resistance