Effect of prophylactic intravenous administration of dexmedetomidine on respiratory cycle and oxidative stress during anesthesia induction

Objective To observe the effect of prophylactic intravenous administration of dexmedetomidine on respiratory cycle and oxidative stress during anesthesia induction. Methods Forty patients undergoing abdominal surgery from March 2014 to August 2016 in Jingjiang Traditional Chinese Medicine Hospital were selected. The patients were divided into experimental group and control group, with 20 cases in each group. In the experimental group, 0.8 μg/kg dexmedetomidine was intravenously pumped into the body within 10 min before induction of anesthesia, and the control group was given the same amount of sodium chloride physiological solution at the same time. Two groups of patients were anesthetized immediately after drug infusion. The levels of HR, PaO2, PaCO2, SBP, DBP, RR in the two groups were compared at 10 min after entering the operation rom (T1), 10 min after induction of anesthesia (T2), after induction of anesthesia (T3), 3 min after tracheal intubation (T4). At the four time points, the venous blood was centrifged and the supernatant was detected and examined the levels of SOD, CAT, GSH. Sedation score was assessed by Ramsay. Results Compared with the indexes levels at T1, the levels of PaO2, PaCO2, Ramsay at T2, T3, T4 and the levels of HR, SBP, DBP at T3, T4 were significantly different in the control group (P all <0.05). Compared with the indexes levels at T1, the levels of PaO2, Ramsay at T2, T3, T4 and the levels of HR, SBP, DBP at T3, T4 were significantly different in the experimental group (P all <0.05). The Ramsay scores and the levels of PaCO2 and PaO2 at T2, T3 and T4 time points, and the levels of HR, SBP and DBP at T4 time points in the control group were significantly different from those in the experimental group at the same time points (P all <0.05). Compared with the indexes levels at T1, the levels of SOD, CAT and GSH at T3 were significantly different in the control group and the experimental group(P all <0.05). Between the two groups, the levels of SOD, CAT and GSH at T3 in the experimental group were significantly different from those of the control group at T3(P all <0.05). Some mild adverse reactions in the two groups were alleviated after corresponding treatment. Conclusions Dexmedetomidine has good anesthesia effect on patients induced by intravenous general anesthesia, which can effectively relieve the body’s oxidative stress injury, reduce the impact on respiratory and circulatory system, and maintain stable hemodynamics, so it can be widely used in clinics. Key words: Dexmedetomidine; General anesthesia induction; Oxidative stress; Respiratory cycle